Euan Richards
Organic Chemistry, High-Throughput Screening, Bioinformatics & Cheminformatics
I am a multidisciplinary researcher combining computational chemical library design, synthetic organic chemistry, and high-throughput phenotypic screening.
My work focuses on leveraging chemical library design to increase the efficiency of high-throughput target agnostic phenotypic screens including bioinformatic deconvolution, for novel therapeutic discovery.
Experience
Postdoctoral Researcher
ETH Zürich (Bode Group) • 2026 (Jan) - 2026 (Sept)
- Exploration of Large Language Model (LLM) embeddings for direct Cell Painting image analysis
- Structure Activity Relationship (SAR) study using Cell Painting phenotypic screening data
PhD Student in Chemistry
ETH Zürich (Bode Group) • 2020 - 2026
- Automation guided high-throughput hit-finding Cell Painting Screen
- Over 2600 screened conditions, over 118,000 images generated
- Novel Tubulin polymerisation inhibitor discovered and fully characterised
- Bioinformatic normalisation, batch correction, and analysis
- Cheminformatic Library design
- Python workflows converting commercial building block databases into feasible combinatorial library components
- Diversity and physicochemical property screening for targeted library expansion
- Integration of reaction prediction algorithms for building block productivity (and uncertainty) predictions
- Organic Synthesis
- Multi-scale synthesis and analysis of chiral, medicinally relevant building blocks and resultant drug-products
- Developed automated chemical synthesis methodologies for parallelised synthesis strategies
Student Research Associate
Bicycle Therapeutics • 2018 - 2019
- Designing of novel scaffolds for Bicycle Therapeutics’ bicyclic peptide platform
- Optimisation of an MT1-MMP targeting bicyclic peptide (SAR and physicochemical properties) leading to a patent
Student Research Associate
Bicycle Therapeutics • 2018 - 2019
- Designing of novel scaffolds for Bicycle Therapeutics’ bicyclic peptide platform
- Optimisation of an MT1-MMP targeting bicyclic peptide (SAR and physicochemical properties) leading to a patent
Student Research Associate
Bicycle Therapeutics • 2018 - 2019
- Designing of novel scaffolds for Bicycle Therapeutics’ bicyclic peptide platform
- Optimisation of an MT1-MMP targeting bicyclic peptide (SAR and physicochemical properties) leading to a patent
Education
PhD in Chemistry
ETH Zürich, Switzerland • 2020 - 2026
Research Group of Professor Jeffrey W. Bode
Thesis: Development of on-demand chemical libraries for high-content phenotypic screening.
Industrial Thesis
Bicycle Therapeutics, Cambridge, UK • 2018 - 2019
MChem in Chemistry
Durham University, UK • 2015 - 2019
First class honours.
Skills
Organic Synthesis • High-Throughput Screening • Cell Painting • Cheminformatics • Bioinformatics • Machine Learning
Publications, Patents & Talks
- Publication (Manuscript in preparation): On-Demand Chemical Libraries for High-Content ScreeningRichards, E.; O'Hare, S.; Götz, J.; Bode, J.
- Publication (Manuscript in preparation): Chemical library generation and peptide modification from Aminopyridine N-oxides and potassium acyltrifloroboratesSchilling, P.; Richards, E.; Bode, J.
- Publication (Under Review): Precision Oncology: Advancing Cancer Radiotheranostics with the Novel MT1-MMP-Targeting Bicyclic Peptide BCY25286Eder, A. Regupathy, A., Fakiri, M, E., Lahdenranta. J, Domogalla, L. Wood, F. Steinacker, N. Blakeman, B. Uhlmann, L. Sulewska, M. Richards, E. Lani, R. Chen, L. Bennett, G, S. Meyer P, T. Mudd G, E. Eder, M.
- Publication (Science Advances): Predicting three-component reaction outcomes from ~40,000 miniaturized reactant combinationsGötz, J.; Richards, E.; Stepek, I.; Takahashi, Y.; Huang, Y.-L.; Bertschi, L.; Rubi, B.; Bode, J.
- Patent (Bicycle Therapeutics): Bicyclic Peptide Ligands Specific for Mt1-Mmp (US2022024982A1, 2022).Inventors: Chen, L.; Richards, E.; Lani, R.; Mudd, G.; Stace, C.; Teufel, D.; Walker, E.
- Talk: "Enabling an On-Demand Drug Library with High Throughput Synthesis and Cheminformatics" - Gordon Research Seminar, U.S. (2023).
- References: Available upon request.